The clinical applications of fluorouracil in ophthalmic practice
| Autor: | Robert J Casson, Igal Leibovitch, Lekha M. Abraham, Dinesh Selva |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Proliferative vitreoretinopathy
medicine.medical_specialty Antimetabolites Antineoplastic Conjunctiva genetic structures Eye Diseases medicine.medical_treatment Administration Topical Dacryocystorhinostomy Ophthalmologic Surgical Procedures Pharmacotherapy medicine Humans Pharmacology (medical) Eye surgery Adverse effect Cell Proliferation business.industry Eye Neoplasms medicine.disease eye diseases Surgery medicine.anatomical_structure Fluorouracil sense organs business Ophthalmologic Surgical Procedure medicine.drug |
| Zdroj: | Drugs. 67(2) |
| ISSN: | 0012-6667 |
| Popis: | Fluorouracil (5-fluorouracil, 5-FU) is a pyrimidine analogue that was originally known for its widespread use as an anticancer drug. The ability of 5-FU to reduce fibroblastic proliferation and subsequent scarring has made it an important adjunct in ocular and periorbital surgeries. It is used in primary glaucoma filtering surgeries and in reviving failing filtering blebs, in dacryocystorhinostomy, pterygium surgery, and in vitreoretinal surgery to prevent proliferative vitreoretinopathy. In addition, 5-FU is also gaining recognition in the treatment and surgical management of ocular surface malignancies like ocular surface squamous neoplasia; however, the specific action of the drug on highly proliferating cells limits its use in primary acquired melanosis of the conjunctiva. When applied topically, this drug has a low rate of sight-threatening adverse effects, is inexpensive, and is easy to administer, making it an important tool in enhancing the success rate in ophthalmic surgery and in reducing the recurrence of ocular surface neoplasia. |
| Databáze: | OpenAIRE |
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