Haloperidol (but not ziprasidone) withdrawal enhances cocaine-induced locomotor activation and conditioned place preference in mice
| Autor: | Cibele Cristina Chinen, Juliana do Nascimento Alvarez, Julie Anne Obara Tatsu, Roberto Frussa-Filho, Daniela F. Fukushiro, Juliana Castro |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Drug Neuroleptic Drugs media_common.quotation_subject medicine.medical_treatment Motor Activity Pharmacology Mice Cocaine Dopamine Uptake Inhibitors medicine Haloperidol Animals Ziprasidone Biological Psychiatry media_common Analysis of Variance Behavior Animal Dopamine antagonist medicine.disease Conditioned place preference Substance Withdrawal Syndrome Stimulant Substance abuse Conditioning Operant Dopamine Antagonists Psychology medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31:867-872 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2007.01.025 |
| Popis: | It has been empirically suggested that the high incidence of drug abuse in schizophrenic patients is related to chronic neuroleptic treatment. We investigated the effects of withdrawal from long-term administration of the typical neuroleptic haloperidol and/or the atypical agent ziprasidone on the acute locomotor stimulant effect of cocaine as well as on cocaine-induced conditioned place preference (CPP). In the first experiment, mice were i.p. treated with haloperidol (1.0 mg/kg) and/or ziprasidone (4.0 mg/kg) for 15 days. At 72 h after the last injection, animals received an i.p. injection of cocaine (10 mg/kg) and their locomotor activity was quantified. In the second experiment, mice were withdrawn from the same haloperidol or ziprasidone treatment schedule and submitted to CPP. Withdrawal from haloperidol (but not ziprasidone or ziprasidone plus haloperidol) increased both cocaine-induced hyperactivity and CPP. These findings indicate that withdrawal from long-term treatment with typical neuroleptic drugs such as haloperidol (but not the atypical compound ziprasidone) may enhance some behavioral effects of cocaine in mice which have been related to drug dependence in humans. |
| Databáze: | OpenAIRE |
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