Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF
| Autor: | S.K. Krstić, M.K. Krstić, R.M. Stepanović, Vucković Sm |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Vasodilation Pharmacology Nitric Oxide Nitric oxide 03 medical and health sciences chemistry.chemical_compound Lipoxygenase 0302 clinical medicine medicine.artery medicine Animals Common carotid artery 030304 developmental biology 0303 health sciences Relaxation (psychology) biology Chemistry General Medicine 3. Good health Rats medicine.anatomical_structure Carotid Arteries Anesthesia cardiovascular system biology.protein Female Endothelium Vascular 030217 neurology & neurosurgery Methylene blue Histamine Artery |
| Zdroj: | Archives of Physiology and Biochemistry |
| ISSN: | 0778-3124 |
| Popis: | The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF. Scientific Fund of Serbia (Grant No. 231). |
| Databáze: | OpenAIRE |
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