Evaluation of ocular irritancy of coal-tar dyes used in cosmetics employing reconstructed human cornea-like epithelium and short time exposure tests
| Autor: | Ki Taek Nam, Miri Lee, Joo Young Lee, Song E. Lim, Sang Hyeon Yeon, Kyung Min Lim, Jungah Kim, Buhyun Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Ocular irritation media_common.quotation_subject ALIZARIN RED Cosmetics Toxicology Animal Testing Alternatives 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cornea Toxicity Tests Acute Medicine Humans Coal tar Coloring Agents Coal Tar media_common Eosin business.industry Epithelium Corneal Eye irritation General Medicine Anatomy Dermatology Epithelium 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Irritants sense organs business Food Science medicine.drug |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 108 |
| ISSN: | 1873-6351 |
| Popis: | Coal-tar dyes in cosmetics may elicit adverse effects in the skin and eyes. Countries, like the US, have banned the use of coal-tar dyes in cosmetics for the eye area due to the potential for ocular irritation. We evaluated the eye irritation potential of 15 coal-tar dyes permitted as cosmetic ingredients in reconstructed human cornea-like epithelium (RhCEs [EpiOcular™ and MCTT HCE™]) tests and the short time exposure (STE) test. Eosin YS, phloxine B, tetrachlorotetrabromofluorescein, and tetrabromofluorescein were identified as irritants in RhCEs; dibromofluorescein and uranine yielded discrepant results. STE enabled further classification in accordance with the UN Globally Harmonized System of Classification and Labelling of Chemicals, as follows: eosin YS as Cat 2; phloxine B, Cat 1; and tetrachlorotetrabromofluorescein and tetrabromofluorescein, Cat 1/2. STE indicated dibromofluorescein (irritant in EpiOcular™) and uranine (irritant in MCTT HCE™) as No Cat, resulting in the classification of “No prediction can be made.” based on bottom-up approach with each model. These results demonstrated that in vitro eye irritation tests can be utilized to evaluate the potential ocular irritancy of cosmetic ingredients and provide significant evidence with which to determine whether precautions should be given for the use of coal-tar dyes in cosmetics or other substances applied to the eye area. |
| Databáze: | OpenAIRE |
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