Characteristics of Spontaneous Square-Wave Jerks in the Healthy Macaque Monkey during Visual Fixation
| Autor: | Xoana G. Troncoso, Susana Martinez-Conde, Michael B. McCamy, Stephen L. Macknik, Hector Rieiro, Leandro L. Di Stasi, Jorge Otero-Millan, Ali Najafian Jazi, John R. Leigh, Francisco M. Costela |
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| Přispěvatelé: | Barrow Neurological Institute at Phoenix Children’s Hospital, Veterans Affairs Medical Center, Unité de Neurosciences Information et Complexité [Gif sur Yvette] (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Primates
Vision Rhesus monkeys Science [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Fixation Ocular Horizontal saccades Motor Activity Monkeys Macaque MESH: Macaca mulatta MESH: Brain 03 medical and health sciences Saccadic intrusions 0302 clinical medicine biology.animal medicine Saccades Animals Humans MESH: Animals Primate MESH: Fixation Ocular 030304 developmental biology 0303 health sciences MESH: Humans Multidisciplinary [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior biology [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Eye movement Brain medicine.disease Macaca mulatta MESH: Motor Activity Eye movements Saccade Fixation (visual) Spinocerebellar ataxia Medicine MESH: Saccades Eyes Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname PLoS ONE PLoS ONE, Public Library of Science, 2015, 10 (6), pp.e0126485. ⟨10.1371/journal.pone.0126485⟩ PLoS ONE, Vol 10, Iss 6, p e0126485 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0126485⟩ |
| Popis: | Saccadic intrusions (SIs), predominantly horizontal saccades that interrupt accurate fixation, include square-wave jerks (SWJs; the most common type of SI), which consist of an initial saccade away from the fixation target followed, after a short delay, by a return saccade that brings the eye back onto target. SWJs are present in most human subjects, but are prominent by their increased frequency and size in certain parkinsonian disorders and in recessive, hereditary spinocerebellar ataxias. SWJs have been also documented in monkeys with tectal and cerebellar etiologies, but no studies to date have investigated the occurrence of SWJs in healthy nonhuman primates. Here we set out to determine the characteristics of SWJs in healthy rhesus macaques (Macaca mulatta) during attempted fixation of a small visual target. Our results indicate that SWJs are common in healthy nonhuman primates. We moreover found primate SWJs to share many characteristics with human SWJs, including the relationship between the size of a saccade and its likelihood to be part of a SWJ. One main discrepancy between monkey and human SWJs was that monkey SWJs tended to be more vertical than horizontal, whereas human SWJs have a strong horizontal preference. Yet, our combined data indicate that primate and human SWJs play a similar role in fixation correction, suggesting that they share a comparable coupling mechanism at the oculomotor generation level. These findings constrain the potential brain areas and mechanisms underlying the generation of fixational saccades in human and nonhuman primates. This study was supported by Barrow Neurological Foundation (http://www.thebarrow.org/) to SLM and SMC. National Science Foundations (Awards 0852636 and 1153786 to SMC and Award 0726113 to SLM). |
| Databáze: | OpenAIRE |
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