Correlation of Multiple Steroid Receptors with Histological Type and Grade in Human Ovarian Cancer
| Autor: | R. Kuhnel, J F Delemarre, J. G. Stolk, B. R. Rao |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
endocrine system Pathology medicine.medical_specialty medicine.drug_class Endometriosis Brenner Tumor Receptors Cell Surface Ovary Adenocarcinoma Biology Pathology and Forensic Medicine Carcinoma medicine Humans Child skin and connective tissue diseases Receptor Ovarian Neoplasms Obstetrics and Gynecology Neoplasms Germ Cell and Embryonal medicine.disease Androgen Adenocarcinoma Mucinous Serous fluid medicine.anatomical_structure Estrogen Female Ovarian cancer hormones hormone substitutes and hormone antagonists Clear cell |
| Zdroj: | International Journal of Gynecological Pathology. 6:248-256 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/00004347-198709000-00006 |
| Popis: | One hundred eight human ovarian cancers were analyzed for estrogen (ER), progestin (PgR), and androgen (AR) receptors. The receptor levels were related to histological type and grade of the tumor. There were 103 common epithelial carcinomas subdivided into serous (36), endometrioid (36), mucinous (18), clear cell (5), malignant Brenner (3), mixed epithelial (2), and undifferentiated (3) types. Of the remaining five, four were sex cord-stromal tumors and there was a single case of germ cell tumor. ER was detected in 52%, PgR in 52%, and AR in 91% of the cases. There was no correlation between the presence of ER and AR and the tumor histology. The presence of PgR correlated with the grade of endometrioid carcinoma, while no clear correlation existed for the other tumor types. PgR was absent in the three undifferentiated carcinomas. Interestingly, high PgR levels were detected in the three granulosa cell tumors. |
| Databáze: | OpenAIRE |
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