Synthesis and spectroscopic characterization of cannabinolic acid
| Autor: | Arno Hazekamp, Robert Verpoorte, Krishna Prasad Bastola |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Chromatography
Gas Magnetic Resonance Spectroscopy Trimethylsilyl Spectrophotometry Infrared Cannabinol Pharmaceutical Science chemistry.chemical_element Analytical Chemistry Catalysis chemistry.chemical_compound Spectrophotometry Drug Discovery medicine Organic chemistry Humans Cannabis Pharmacology Chloroform medicine.diagnostic_test Chemistry Organic Chemistry Aromatization Complementary and alternative medicine Tetrahydrocannabinolic acid Molecular Medicine Analytical procedures Selenium medicine.drug Phytotherapy |
| Zdroj: | Planta medica. 73(3) |
| ISSN: | 0032-0943 |
| Popis: | Cannabinoids, the main constituents of the cannabis plant, are being increasingly studied for their medicinal properties. Cannabinolic acid (CBNA; 1) was synthesized from tetrahydrocannabinolic acid (THCA; 2), a major constituent of the cannabis plant, by aromatization using selenium dioxide mixed with trimethylsilyl polyphosphate as catalyst in chloroform. Purification was achieved by centrifugal partition chromatography, and the final product had a purity of over 96% by GC analysis. Spectroscopic data on CBNA such as 1H-NMR and IR, and molar extinction coefficients, as well as chromatographic data are presented as useful references for further research on CBNA. The developed method allows production of CBNA on a preparative scale, making it available for further studies on its biological activities as well as use as a reference standard for analytical procedures. |
| Databáze: | OpenAIRE |
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