Differential Expression Patterns of EGF, EGFR, and ERBB4 in Nasal Polyp Epithelium
| Autor: | Tian Ying Li, Chun Wei Li, Li Shi, Li Zhao, Somasundaram Subramaniam, Chen Duan, Liang Shen, Xue Min Yu, De Hua Chen, Yingying Li, De Yun Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Keratinocytes Male Pathology Receptor ErbB-4 Neutrophils Cellular differentiation lcsh:Medicine Mucous membrane of nose Pathology and Laboratory Medicine Epithelium Basal (phylogenetics) White Blood Cells 0302 clinical medicine Epidermal growth factor Animal Cells Medicine and Health Sciences Nasal polyps Receptor lcsh:Science Immune Response Staining Multidisciplinary Cell Staining Cell Differentiation Middle Aged Basal Cells ErbB Receptors medicine.anatomical_structure 030220 oncology & carcinogenesis Female Anatomy Cellular Types Research Article Adult medicine.medical_specialty Immune Cells Immunology Biology Research and Analysis Methods Basal Cell Hyperplasia 03 medical and health sciences Young Adult Signs and Symptoms Nasal Polyps Diagnostic Medicine medicine Humans Regeneration Immunohistochemistry Techniques Inflammation Blood Cells Epidermal Growth Factor Gene Expression Profiling lcsh:R Biology and Life Sciences Epithelial Cells Cell Biology medicine.disease Molecular biology Histochemistry and Cytochemistry Techniques Nasal Mucosa 030104 developmental biology Biological Tissue Specimen Preparation and Treatment Case-Control Studies Immunologic Techniques lcsh:Q Developmental Biology |
| Zdroj: | PLoS ONE, Vol 11, Iss 6, p e0156949 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Epidermal growth factor receptors play an important role in airway epithelial cell growth and differentiation. The current study investigates the expression profiles of EGF, EGFR and ERBB4 in patients with nasal polyps (NP), and their response to glucocorticosteroid (GC) treatment. Fifty patients with NP (40 without GC treatment and 10 with oral GC) and 20 control subjects with septal deviation were recruited into the study. Protein levels of EGF, EGFR, and ERBB4 were evaluated by immune-staining. In healthy nasal epithelium, EGF and EGFR localized within p63+ basal cells, while ERBB4 localized within ciliated cells. GC-naive NP epithelium showed weak expression of EGF in 90% of samples versus 5% of controls. EGFR was significantly increased in the epithelium with basal cell hyperplasia from GC-naive NPs (78%, 31/40) compared to controls (23%, 4/17). EGFR was also found in some degranulating goblet cells. ERBB4 expression was significantly higher in hyperplastic epithelium from GC-naive NPs (65%, 26/40) than in controls (6%, 1/17). GC treatment restored the EGF expression and normalized the EGFR and ERBB4 expression in NPs. Differential expression patterns of EGF, EGFR, and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium. |
| Databáze: | OpenAIRE |
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