| Autor: |
Goering, W, Adham, I M, Pasche, B, Manner, J, Ochs, M, Engel, W, Zoll, B |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Goering, W; Adham, I M; Pasche, B; Manner, J; Ochs, M; Engel, W; Zoll, B (2008). Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice. Cytogenetic and genome research, 121(2), pp. 88-95. Basel: Karger 10.1159/000125833 |
| DOI: |
10.1159/000125833 |
| Popis: |
The mouse Foxq1 gene, also known as Hfh1 , encodes a winged helix/forkhead transcription factor. In adult mice, Foxq1 is highly expressed in kidney and stomach. Here, we report that Foxq1 is expressed during prenatal and postnatal stomach development and the transcripts are restricted to acid secreting parietal cells. Mice homozygous for a deletion of the Foxq1 locus on a 129/Sv ! C57BL/6J hybrid genetic background display variable phenotypes consistent with requirement of the gene during embryogenesis. Approximately 50% of Foxq1– /– embryos die in utero. W.G and I.M.A. contributed equally to this study. Request reprints from Wolfgang Engel Institute for Human Genetics, University of Göttingen Heinrich-Düker-Weg 12, DE–37073 Göttingen (Germany) telephone: +49 551 397589; fax: +49 551 399303 e-mail: wengel@gwdg.de © 2008 S. Karger AG, Basel 1424–8581/08/1212–0088$24.50/0 Accessible online at: www.karger.com/cgr Surviving homozygous mutants are normal and fertile, and have a silky shiny coat. Although the parietal cell development is not affected in the absence of Foxq1 , there is a lack of gastric acid secretion in response to various secretagogue stimuli. Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1 -deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi. peerReviewed |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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