Anxiolytic-like effect of the monoterpene 1,4-cineole in mice
| Autor: | Damião Pergentino de Sousa, Emmanuelle Coelho Noronha, Mariana Lima Feitosa, Francisca Cléa Florenço de Sousa, Emiliano Ricardo Vasconcelos Rios, Silvânia Maria Mendes Vasconcelos, Brinell Arcanjo Moura, Patricia Bezerra Gomes, Maria Izabel Gomes Silva, E.T. Venâncio, Marta Maria de França Fonteles |
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| Rok vydání: | 2010 |
| Předmět: |
Pentobarbital
Elevated plus maze medicine.drug_class Monoterpene Clinical Biochemistry Cyclohexane Monoterpenes Pharmacology Toxicology Biochemistry Anxiolytic Imipramine Open field Mice Behavioral Neuroscience medicine Animals Biological Psychiatry Behavior Animal Chemistry Motor coordination Anti-Anxiety Agents Anesthesia Monoterpenes Diazepam medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 96:287-293 |
| ISSN: | 0091-3057 |
| Popis: | Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically the elevated plus maze (EPM), hole board, open field, pentobarbital sleeping time, forced swimming, tail suspension and rota rod tests. 1,4-Cineole was administered orally to mice (100, 200 and 400 mg/kg), while diazepam (1 or 2 mg/kg) and imipramine (10 or 30 mg/kg) were used as standard drugs. 1,4-Cineole (400 mg/kg) modified all parameters observed in the EPM, while no significant variation was observed on general motor activity in the open-field test. In the hole-board assay, 1,4-cineole induced increase on the number of head dips. Forced swimming and tail suspension tests showed that cineole (200 and/or 400 mg/kg) was able to promote significant increase on the immobility time, while a decreased sleep latency was observed (200 and 400 mg/kg ) on the pentobarbital sleeping time. Cineole had no effect on the motor coordination of animals in the rota rod test. The results suggest that 1,4-cineole presents potential anxiolytic-like action consistent with possible general depression of the CNS. |
| Databáze: | OpenAIRE |
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