Selenium and selenoproteins in prostanoid metabolism and immunity
| Autor: | K. Sandeep Prabhu, Fenghua Qian, Sougat Misra |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Thromboxane
chemistry.chemical_element Prostaglandin Biochemistry Article Selenium chemistry.chemical_compound Immunity Animals Humans Selenoproteins Molecular Biology Randomized Controlled Trials as Topic Inflammation chemistry.chemical_classification Selenocysteine biology Lipid Metabolism Prostanoid metabolism Amino acid chemistry Prostaglandins biology.protein Cyclooxygenase Signal Transduction |
| Zdroj: | Crit Rev Biochem Mol Biol |
| ISSN: | 1549-7798 1040-9238 |
| DOI: | 10.1080/10409238.2020.1717430 |
| Popis: | Selenium (Se) is an essential trace element that functions in the form of the 21(st) amino acid, selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with pathological conditions in humans and animals, where incorporation of Sec into selenoproteins is reduced along with their expression and catalytic activity. Supplementation of Se-deficient population with Se has shown health benefits suggesting the importance of Se in physiology. An interesting paradigm to explain, in part, the health benefits of Se stems from the observations that selenoprotein-dependent modulation of inflammation and efficient resolution of inflammation relies on mechanisms involving a group of bioactive lipid mediators, prostanoids, which orchestrate a concerted action towards maintenance and restoration of homeostatic immune responses. Such an effect involves the interaction of various immune cells with these lipid mediators where cellular redox gatekeeper functions of selenoproteins further aid in not only dampening inflammation, but also initiating an effective and active resolution process. Here we have summarized the current literature on the multifaceted roles of Se/selenoproteins in the regulation of these bioactive lipid mediators and their immunomodulatory effects. |
| Databáze: | OpenAIRE |
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