Identification and characterization of degradation products of dicloxacillin in bulk drug and pharmaceutical dosage forms
| Autor: | K. Ranga Rao, T. Joseph Sunder Raj, Kalpesh Parikh, C.H. Bharati, G.K.A.S.S. Narayan, P. Satyanarayana Rao |
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| Rok vydání: | 2006 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Clinical Biochemistry Pharmaceutical Science Capsules Mass spectrometry Dicloxacillin High-performance liquid chromatography Dosage form Mass Spectrometry Analytical Chemistry Drug Stability Impurity Spectrophotometry Drug Discovery medicine Spectroscopy Antibacterial agent Chromatography medicine.diagnostic_test Molecular Structure Chemistry Nuclear magnetic resonance spectroscopy Anti-Bacterial Agents Pharmaceutical Preparations Drug Contamination medicine.drug Chromatography Liquid |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 43(4) |
| ISSN: | 0731-7085 |
| Popis: | Impurity profiling of dicloxacillin sodium bulk drug and pharmaceutical dosage forms subjected to stability studies is evaluated. Of many impurities detected in HPLC analysis, three were not reported in the literature. The impurities have been identified by LC-MS; isolated by preparative HPLC; and characterised by NMR, Mass spectroscopy and IR. Pure impurities obtained by isolation were co-injected with dicloxacillin sodium sample to confirm the retention times in HPLC. Structure elucidation of these degradation products by spectral data has been discussed in detail. |
| Databáze: | OpenAIRE |
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