Improved coronary calcification quantification using photon-counting-detector CT: an ex vivo study in cadaveric specimens
| Autor: | Shengzhen Tao, Kishore Rajendran, Shuai Leng, Mårten Sandstedt, Hao Gong, Jeffrey F. Marsh, Cynthia H. McCollough, Anders Persson |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Tomography Scanners X-Ray Computed Wilcoxon signed-rank test Article 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences symbols.namesake 0302 clinical medicine Image noise Cadaver Medicine Humans Radiology Nuclear Medicine and imaging Photons business.industry Phantoms Imaging Ultrasound General Medicine medicine.disease Thresholding Bonferroni correction Kernel (image processing) Friedman test 030220 oncology & carcinogenesis symbols Radiology business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | Eur Radiol |
| ISSN: | 1432-1084 |
| Popis: | To compare the accuracy of coronary calcium quantification of cadaveric specimens imaged from a photon-counting detector (PCD)-CT and an energy-integrating detector (EID)-CT. Excised coronary specimens were scanned on a PCD-CT scanner, using both the PCD and EID subsystems. The scanning and reconstruction parameters for EID-CT and PCD-CT were matched: 120 kV, 9.3–9.4 mGy CTDIvol, and a quantitative kernel (D50). PCD-CT images were also reconstructed using a sharper kernel (D60). Scanning the same specimens using micro-CT served as a reference standard for calcified volumes. Calcifications were segmented with a half-maximum thresholding technique. Segmented calcified volume differences were analyzed using the Friedman test and post hoc pairwise Wilcoxon signed rank test with the Bonferroni correction. Image noise measurements were compared between EID-CT and PCD-CT with a repeated-measures ANOVA test and post hoc pairwise comparison with the Bonferroni correction. A p PCD-D50 > PCD-D60 > micro-CT. The median calcified volumes in EID-D50, PCD-D50, PCD-D60, and micro-CT were 22.1 (IQR 10.2–64.8), 21.0 (IQR 9.0–56.5), 18.2 (IQR 8.3–49.3), and 14.6 (IQR 5.1–42.4) mm3, respectively (p < 0.05 for all pairwise comparisons). The average image noise in EID-D50, PCD-D50, and PCD-D60 was 60.4 (± 3.5), 56.0 (± 4.2), and 113.6 (± 8.5) HU, respectively (p < 0.01 for all pairwise comparisons). The PCT-CT system quantified coronary calcifications more accurately than EID-CT, and a sharp PCD-CT kernel further improved the accuracy. The PCD-CT images exhibited lower noise than the EID-CT images. • High spatial resolution offered by PCD-CT reduces partial volume averaging and consequently leads to better morphological depiction of coronary calcifications. • Improved quantitative accuracy for coronary calcification volumes could be achieved using high-resolution PCD-CT compared to conventional EID-CT. • PCD-CT images exhibit lower image noise than conventional EID-CT at matched radiation dose and reconstruction kernel. |
| Databáze: | OpenAIRE |
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