Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
| Autor: | Alejandro Tapia, Gabriela Egly Feresin, Mariana Rey, Maria Sol Kruse, Jessica Gómez, Mario J. Simirgiotis, Héctor Coirini, Rocío N. Magrini-Huamán |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty Normal diet UHPLC-PDA-OT-MS/MS phenolic compounds analysis Endocrinology Diabetes and Metabolism Decoction Biochemistry Microbiology Article triglyceride metabolism chemistry.chemical_compound nuclear receptors (LXR PPAR RXR) In vivo Internal medicine medicine brain lipid metabolism caffeoylquinic acid dietary fat Liver X receptor Molecular Biology medicine.diagnostic_test Cholesterol nutritional and metabolic diseases musculoskeletal system QR1-502 Caffeoylquinic acid Endocrinology chemistry Hypothalamus bacteria lipids (amino acids peptides and proteins) sense organs Lipid profile |
| Zdroj: | Metabolites, Vol 11, Iss 579, p 579 (2021) Metabolites; Volume 11; Issue 9; Pages: 579 Metabolites |
| ISSN: | 2218-1989 |
| Popis: | Chronic high-fat diet consumption induces hypercholesterolemia. The effect of Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver X receptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or a high-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W) or a decoction of the aerial parts of T. absinthioides (Ta; 10% w/v) for 2, 4, or 6 weeks. Four and six weeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression of LXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied with an ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC–PDA–OT-MS/MS). Fifty-one compounds were identified, of which twelve are reported for the first time. Among these compounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expression of LXRs. This is the first in vivo report of T. absinthioides, which may be a potential candidate against hypercholesterolemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|