miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment
| Autor: | Ying‑Fu Liu, Guang‑Zong Li, Xiao‑Yi Chen, Feng Chen, Ren‑Jie Wang, Shuo Yu, Yi Zhang, Shi‑Ke Hou |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cancer Research Spliceosome microRNA array Biology Environment Biochemistry 03 medical and health sciences 0302 clinical medicine high altitude hypoxia Downregulation and upregulation microRNA Genetics Animals Circulating MicroRNA KEGG Hypoxia Molecular Biology Gene Regulation of gene expression Oncogene Altitude Computational Biology Reproducibility of Results Articles signaling pathways Cell biology Rats MicroRNAs 030104 developmental biology Gene Ontology Oncology Gene Expression Regulation 030220 oncology & carcinogenesis Molecular Medicine Gene-Environment Interaction Blood Gas Analysis |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | In the present study, the microRNA (miRNA) expression profiles of rats exposed to high altitude hypoxia and normal conditions were obtained from miRNA array analysis. Bioinformatics analyses, including the use of the Gene Oncology and Kyoto Encyclopedia of Genes and Genomes databases, were used to identify the genes and pathways, which were specifically associated with high altitude hypoxic environment‑associated miRNAs. A total of 26 miRNAs were differentially expressed in the two groups, comprising six upregulated and 20 downregulated miRNAs. In the present study, a novel pattern of upregulated miRNAs and their associated pathways were constructed, including proteoglycans in cancer, spliceosome, gluamatergic synapse, glycolysis/gluconeogenesis, Foxo, cGMP‑PKG and p53 signaling pathways, which may provide novel targets for diagnosing and understanding the mechanism of high altitude hypoxia‑induced disease. |
| Databáze: | OpenAIRE |
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