Plasma levels of lipoproteins and apolipoproteins in congenital hypothyroidism: Effects of l-thyroxine substitution therapy
| Autor: | Angelo B. Cefalù, Andrea Liotta, Cristina Maggio, Stefania La Grutta, Carlo M. Barbagallo, Alberto Notarbartolo, Maurizio Averna, Lucia Casimiro |
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| Přispěvatelé: | Barbagallo, C, Averna, M, Liotta, A, La Grutta, S, Maggio, C, Casimiro, L, Cefalù, A, Notarbartolo, A |
| Rok vydání: | 1995 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Apolipoprotein B Lipoproteins Endocrinology Diabetes and Metabolism Thyrotropin Triglyceride chemistry.chemical_compound Endocrinology Hypothyroidism Internal medicine Blood plasma Congenital Hypothyroidism Humans Medicine Lipoprotein Triglycerides Triiodothyronine Apolipoprotein A-I biology business.industry Cholesterol Thyroid Infant Newborn Infant medicine.disease Apolipoprotein Apolipoproteins Lipoproteins HDL Thyroxine Lipoproteins LDL Female Congenital hypothyroidism medicine.anatomical_structure chemistry biology.protein lipids (amino acids peptides and proteins) business Human Hormone |
| Zdroj: | Metabolism. 44:1283-1287 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(95)90030-6 |
| Popis: | Thyroid status in humans is an important factor in the regulation of lipoprotein metabolism. There are several data on hypothyroidism in the adult population, but less information is available about congenital hypothyroidism. Since lipid metabolism at birth is substantially different from that of adults, it is not likely that the same abnormalities that occur in adult hypothyroidism are also present when this is diagnosed at early life. We studied 16 subjects with congenital hypothyroidism, seven at the time of diagnosis and also after normalization of thyroid hormone levels over a period of 2.0 +/- 1.0 months of substitution therapy with L-thyroxine (5.9 +/- 1.2 micrograms/kg/d) and nine already on L-thyroxine therapy for a period of 4.7 +/- 3.2 months. Thirty-nine apparently healthy subjects matched for age were selected as controls. In all subjects, total cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol (HDL-C), apolipoproteins (apo) A-I and B, lipoprotein(a) [Lp(a)] thyrotropin (TSH), (LDL-C), total and free thyroxine (T4), and triiodothyronine (T3) were determined. CHO, HDL-C, and apo A-I levels were significantly higher in patients at the time of diagnosis than in controls (respectively, P = .0079, .0007, and .0004), whereas TG, LDL-C, apo B, and Lp(a) levels were not significantly different. During L-thyroxine substitution therapy in these subjects, HDL-C and apo A-I levels significantly decreased (respectively, by a mean of -36.2% and -24.4%), with similar behavior in all subjects.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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