Antimicrobial Drug Resistance in Pathogens Causing Nosocomial Infections at a University Hospital in Taiwan, 1981-1999

Autor: Li-Seh Yang, Kwen-Tay Luh, Chin-Yu Lee, Po-Ren Hsueh, Wei-Chuan Hsieh, Mei-Ling Chen, Shan-Chwen Chang, Shen-Wu Ho, Hui-Ju Pan, Chun-Chuan Sun, W. Chen
Jazyk: angličtina
Rok vydání: 2002
Předmět:
Tiagabine
lcsh:Medicine
Cefotaxime
Drug resistance
Epilepsy
Anti-Infective Agents
bacterial pathogens
Drug Interactions
Escherichia coli Infections
Candida
Cross Infection
Valproic Acid
Candidiasis
Anti-Bacterial Agents
Enzyme Induction
Pseudomonas aeruginosa
Microsomes
Liver
Anticonvulsants
Female
medicine.drug
Topiramate
Staphylococcus aureus
medicine.medical_specialty
Gabapentin
medicine.drug_class
Taiwan
Microbial Sensitivity Tests
Contraceptives
Oral
Hormonal
lcsh:Infectious and parasitic diseases
Drug Resistance
Fungal
Internal medicine
Drug Resistance
Bacterial
medicine
nosocomial infections
Humans
Pseudomonas Infections
lcsh:RC109-216
antimicrobial resistance
Intensive care medicine
business.industry
Research
lcsh:R
Carbamazepine
medicine.disease
hospital-based surveillance
Estrogen
Quality of Life
Methicillin Resistance
business
Zdroj: Emerging Infectious Diseases, Vol 8, Iss 1, Pp 63-68 (2002)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: To determine the distribution and antimicrobial drug resistance in bacterial pathogens causing nosocomial infections, surveillance data on nosocomial infections documented from 1981 to 1999 at National Taiwan University Hospital were analyzed. During this period, 35,580 bacterial pathogens causing nosocomial infections were identified. Candida species increased considerably, ranking first by 1999 in the incidence of pathogens causing all nosocomial infections, followed by Staphylococcus aureus and Pseudomonas aeruginosa. Candida species also increased in importance as bloodstream infection isolates, from 1.0% in 1981-1986 to 16.2% in 1999. The most frequent isolates from urinary tract infections were Candida species (23.6%), followed by Escherichia coli (18.6%) and P. aeruginosa (11.0%). P. aeruginosa remained the most frequent isolates for respiratory tract and surgical site infections in the past 13 years. A remarkable increase in incidence was found in methicillin-resistant S. aureus (from 4.3% in 1981-1986 to 58.9% in 1993-1998), cefotaxime-resistant E. coli (from 0% in 1981-1986 to 6.1% in 1993-1998), and cefotaxime-resistant Klebsiella pneumoniae (from 4.0% in 1981-1986 to 25.8% in 1993-1998). Etiologic shifts in nosocomial infections and an upsurge of antimicrobial resistance among these pathogens, particularly those isolated from intensive care units, are impressive and alarming.
Databáze: OpenAIRE
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