Prevention of Preterm Birth with Progesterone
| Autor: | Gian Carlo Di Renzo, Eduardo Borges da Fonseca, Valentina Tosto, V. I. Tsibizova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pregnancy
medicine.medical_specialty business.industry Obstetrics Public health Prostaglandin synthesis Early detection Gestational age preterm birth Clinical settings General Medicine Review medicine.disease Infant mortality prevention Infant morbidity recommendations perinatal outcomes medicine 17-OHPC risk factors Medicine business micronized progesterone |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 4511, p 4511 (2021) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Gestational age at birth is a critical factor for perinatal and adulthood outcomes, and even for transgenerational conditions’ effects. Preterm birth (PTB) (prematurity) is still the main determinant for infant mortality and morbidity leading cause of infant morbidity and mortality. Unfortunately, preterm birth (PTB) is a relevant public health issue worldwide and the global PTB rate is around 11%. The premature activation of labor is underlined by complex mechanisms, with a multifactorial origin influenced by numerous known and probably unknown triggers. The possible mechanisms involved in a too early labor activation have been partially explained, and involve chemokines, receptors, and imbalanced inflammatory paths. Strategies for the early detection and prevention of this obstetric condition were proposed in clinical settings with interesting results. Progesterone has been demonstrated to have a key role in PTB prevention, showing several positive effects, such as lower prostaglandin synthesis, the inhibition of cervical stromal degradation, modulating the inflammatory response, reducing gap junction formation, and decreasing myometrial activation. The available scientific knowledge, data and recommendations address multiple current areas of debate regarding the use of progesterone in multifetal gestation, including different formulations, doses and routes of administration and its safety profile in pregnancy. |
| Databáze: | OpenAIRE |
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