Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men
| Autor: | Keiki Ogino, Kei Takemoto, Yu Zou, Kiyomi Inoue, Da Hong Wang, Noriko Sakano, Kazuhisa Taketa, Masayuki Kubo, Yoshie Sato, Suketaka Iwanaga, Chie Masatomi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment alcohol consumption alpha-Tocopherol serum retinol lcsh:Medicine gamma-Tocopherol Biology Antioxidants Article smoking chemistry.chemical_compound Young Adult Lipid oxidation Reference Values Internal medicine medicine Humans Insulin serum α-tocopherol HOMA-R Tocopherol Young adult Beta (finance) Vitamin A Aged serum alpha-tocopherol serum γ-tocopherol lcsh:R Public Health Environmental and Occupational Health Retinol serum ferritin Middle Aged Endocrinology Cross-Sectional Studies chemistry Ferritins serum gamma-tocopherol Biomarkers |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 11 Issue 2 Pages 1647-1660 International Journal of Environmental Research and Public Health, Vol 11, Iss 2, Pp 1647-1660 (2014) |
| ISSN: | 1660-4601 |
| Popis: | Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = −0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = −0.262, p = 0.021), α-tocopherol (β = −0.236, p = 0.035), and γ-tocopherol levels (β = −0.224, p = 0.052) and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = −0.286, p = 0.008) and γ-tocopherol (β = −0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = −0.211, p = 0.032) and α-tocopherol levels (β = −0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. |
| Databáze: | OpenAIRE |
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