Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Autor: Udia Pius Monday, Ghasi Samuel Ikenna, Akpan Joseph Linus, Ezeokpo Basil Chukwuma, Akuodor Godwin Christian, Nwadike Kenneth Ikechukwu, Okezie Ogwuegbu Alozie
Rok vydání: 2015
Předmět:
Zdroj: Journal of Coastal Life Medicine, Vol 3, Iss 9, Pp 728-732 (2015)
ISSN: 2309-6152
2309-5288
DOI: 10.12980/jclm.3.2015j5-91
Popis: Objective: To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus, a plant used in herbal medicine for the management of various diseases in Nigeria. Methods: Ethanol-, acetylsalicylic acid-, histamine- and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf extract. Acute toxicity studies were also carried out. Results: The ethanolic leaf extract significantly (P < 0.05) reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/kg. The LD50 values obtained were greater than 5 000 mg/kg in rats. Conclusions: The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents.
Databáze: OpenAIRE
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