Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models
Autor: | Udia Pius Monday, Ghasi Samuel Ikenna, Akpan Joseph Linus, Ezeokpo Basil Chukwuma, Akuodor Godwin Christian, Nwadike Kenneth Ikechukwu, Okezie Ogwuegbu Alozie |
---|---|
Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Journal of Coastal Life Medicine, Vol 3, Iss 9, Pp 728-732 (2015) |
ISSN: | 2309-6152 2309-5288 |
DOI: | 10.12980/jclm.3.2015j5-91 |
Popis: | Objective: To evaluate the antiulcer activity of ethanolic leaf extract of Byrsocarpus coccineus, a plant used in herbal medicine for the management of various diseases in Nigeria. Methods: Ethanol-, acetylsalicylic acid-, histamine- and water immersion stress-induced gastric ulcers in rats were used to investigate the antiulcer activity of the leaf extract. Acute toxicity studies were also carried out. Results: The ethanolic leaf extract significantly (P < 0.05) reduced the ulcer index in all assays used with the maximal antiulcer activity recorded at 400 mg/kg. The LD50 values obtained were greater than 5 000 mg/kg in rats. Conclusions: The implication of this finding is that Byrsocarpus coccineus ethanolic leaf extract possesses potent antiulcer activity and the leaf of this plant can serve as a potential source of safe and affordable antiulcer agents. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.