Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia
| Autor: | Shu-Ching Yu, Tsung-Ying Chen, Ying-Hsin Chen, Yu-Chang Hung, Ming-Yang Lee, E-Jian Lee, Tian Shung Wu, Hung-Yi Chen, I-Chuan Chuang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
Time Factors Lipopolysaccharide medicine.medical_treatment Ischemia Pharmacology Neuroprotection Hippocampus Antioxidants Lignans Brain ischemia Lipid peroxidation Rats Sprague-Dawley chemistry.chemical_compound Organ Culture Techniques Developmental Neuroscience In vivo Polysaccharides Phenethylamines medicine Animals Benzothiazoles Hypoxia Nitrites Cell Line Transformed Peroxidase Analysis of Variance Nitrates Dose-Response Relationship Drug business.industry Interleukin-6 Tumor Necrosis Factor-alpha Body Weight Guaiacol medicine.disease Rats Dose–response relationship Disease Models Animal Glucose Neurology chemistry Animals Newborn Ischemic Attack Transient Anesthesia Reperfusion Injury Lipid Peroxidation Microglia Sulfonic Acids business |
| Zdroj: | Experimental neurology. 217(1) |
| ISSN: | 1090-2430 |
| Popis: | Cinnamophilin (CINN, (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan) protects against ischemic stroke in mice. While some anti-oxidative effects of CINN have been characterized, its therapeutic window and molecular basis for neuroprotection remain unclear. We evaluated antioxidant and anti-inflammatory properties and therapeutic window of CINN against brain ischemia using a panel of in vitro and in vivo assays. Data from lipid peroxidation and radical scavenging assays showed that CINN was a robust antioxidant and radical scavenger. CINN effectively inhibited the production of tumor necrosis factor alpha (TNF-alpha), nitrite/nitrate, interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells (P |
| Databáze: | OpenAIRE |
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