A Frailty Assessment Tool to Predict In-Hospital Mortality in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
| Autor: | Li-Jie Zheng, Jin-Jin Gu, Qiang Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
China
medicine.medical_specialty Exacerbation Frailty Index FI-Lab Pulmonary disease International Journal of Chronic Obstructive Pulmonary Disease Logistic regression Severity of Illness Index Pulmonary Disease Chronic Obstructive 03 medical and health sciences DECAF 0302 clinical medicine Internal medicine Humans Medicine Eosinopenia In patient Hospital Mortality 030212 general & internal medicine Original Research Aged COPD frailty index AECOPD Frailty business.industry Atrial fibrillation General Medicine Prognosis medicine.disease 030228 respiratory system Disease Progression business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s300980 |
| Popis: | Jin-Jin Gu,1 Qiang Liu,2 Li-Jie Zheng3 1Department of Geriatrics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, People’s Republic of China; 2Department of Laboratory Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, People’s Republic of China; 3Department of Laboratory Medicine,The Affiliated People’s Hospital of Jiangsu University, Zhejiang, 212002, People’s Republic of ChinaCorrespondence: Jin-Jin GuDepartment of Geriatrics, The Affiliated People’s Hospital of Jiangsu University, No. 8 Dianli Road, Zhenjiang, 212002, People’s Republic of ChinaTel +86 511 88915421Email GuJj@jskfhn.org.cnBackground: The exacerbation of chronic obstructive pulmonary disease (AECOPD) is a chronic, frequent, and life-threatening lung disease. In 2014, a frailty index (FI) based on deficits in commonly used laboratory tests (FI-Lab) was suggested to identify older adults at increased risk of death.Objective: We aim to study the prognostic value of the FI-Lab in older Chinese patients who were admitted because of AECOPD.Methods: We screened 1932 older patients hospitalized with AECOPD from September 2016 to June 2019 at Zhenjiang First People’s Hospital, China. A multivariate logistic regression analysis was used to identify prognostic factors for in-hospital mortality.Results: A total of 77 survivors and 77 non-survivors were finally included in the study. Both the mean DECAF (including dyspnea, eosinopenia, consolidation, acidemia, and atrial fibrillation) score and the mean FI-Lab value of non-survivors were statistically higher than those of survivors (4.45 ± 0.80 versus 3.03 ± 0.90, P=0.000; 0.51 ± 0.13 versus 0.29 ± 0.10, P=0.000, respectively). Logistic regression analysis suggested that DECAF Rank and FI-Lab Rank were strongly related factors of death in AECOPD patients. The areas under the receiver-operating characteristic (ROC) curves were 0.906 for FI-Lab and 0.870 for DECAF (P=0.2991).Conclusion: FI-Lab is a simple, efficient, and objective tool to stratify the risk of in-hospital mortality of AECOPD.Keywords: frailty index, FI-Lab, DECAF, AECOPD, prognosis |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|