Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin
Autor: | Saman Siddiquie, Anuradha Mishra, Aftab Siddiqui, Anas Islam |
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Rok vydání: | 2021 |
Předmět: |
Phytochemicals
Active components Antioxidants Silybum marianum 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Drug Discovery Flavonolignan Humans Milk Thistle Medicine 030304 developmental biology Hepatitis 0303 health sciences biology Traditional medicine business.industry Family Asteraceae Liver Diseases General Medicine biology.organism_classification Antimicrobial medicine.disease Phytochemical Silybin 030220 oncology & carcinogenesis business Silymarin |
Zdroj: | Drug Research. 71:489-503 |
ISSN: | 2194-9387 2194-9379 |
Popis: | Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM) belonging to the family Asteraceae. It is a flavonolignan complex and consists of various compounds like silybin A silybin B, isosilybin A, isosilybin B, silydianin, silychristin and isosilychristin. Silybin is the major active component present in 60–70% of the silymarin extract. It has been used traditionally for the treatment of various liver disorders like cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and anti-inflammatory properties and is responsible for its antitumor activity. Other than hepatoprotective effect SM also possesses renoprotective, anti-diabetic, neuroprotective, hypolipidemic, anti-atherosclerosis and cardioprotective effects. Rather antimicrobial property of silymarin was observed against specific microbes, fungi, and viruses. This manuscript covered recent preclinical and clinical evidence of specific components silybin, responsible for its efficacy and about clinical studies has been conducted so far, which proven it’s safety and offers mild effect like nausea, diarrhea and bloating. This review specifically focused on recent updates on its active components therapeutic applications against complicated ailments not covered in earlier reports. |
Databáze: | OpenAIRE |
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