Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study
| Autor: | Wouter W.A. Zuurmond, Bob J. van Hilten, Jaap J. de Lange, Roberto S.G.M. Perez, Susan Collins |
|---|---|
| Přispěvatelé: | Anesthesiology, Human genetics, EMGO - Musculoskeletal health, ICaR - Ischemia and repair |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Blinding SF-36 Adolescent Pilot Projects Motor Activity Sitting Ambulatory Care Facilities law.invention Disability Evaluation Magnesium Sulfate Young Adult Randomized controlled trial Quality of life Double-Blind Method law Surveys and Questionnaires medicine Humans Physical Therapy Modalities Pain Measurement business.industry General Medicine Middle Aged medicine.disease Reflex Sympathetic Dystrophy Anesthesiology and Pain Medicine Complex regional pain syndrome Pain Clinics McGill Pain Questionnaire Injections Intravenous Physical therapy Quality of Life Female Neurology (clinical) business |
| Zdroj: | Collins, S, Zuurmond, W W A, de Lange, J J, van Hilten, B J & Perez, R S G M 2009, ' Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study ', Pain Medicine, vol. 10, no. 5, pp. 930-940 . https://doi.org/10.1111/j.1526-4637.2009.00639.x Pain Medicine, 10(5), 930-940. VICER Publishing |
| ISSN: | 1526-4637 1526-2375 |
| DOI: | 10.1111/j.1526-4637.2009.00639.x |
| Popis: | Objectives. To explore the feasibility of intravenous magnesium administration as a potential candidate intervention for a large size trial in Complex Regional Pain Syndrome Type 1 (CRPS 1). Design. Randomized clinical trial. Setting. Outpatient pain clinic. Patients. Ten CRPS 1 patients. Interventions. Eight patients received 70 mg/kg magnesium sulphate infusions in 4 hours for 5 days. For blinding purposes, 2 patients received equal amount NaCl 0.9% solutions (data not analyzed or presented). Interventions were accompanied by standardized physical therapy. Outcome Measures. Pain was assessed using an 11-point Box scale (three times daily for a week) and the McGill Pain Questionnaire. Skin sensitivity was measured with the Semmes Weinstein Monofilaments, (other) impairments with the Impairment Level Sumscore. In addition, functional limitations (Radboud Skills Questionnaire, questionnaire rising and sitting down) and quality of life (Short Form-36 [SF-36], EuroQol) were evaluated. Assessments were performed at baseline, 1, 3, 6, and 12 weeks after intervention. Results. Mild systemic side effects were experienced and the infusions were locally well tolerated. Pain was significantly reduced at all follow up compared with baseline (T1: P = 0.01, T3: P = 0.04, T6: P = 0.02, T12: P = 0.02). McGill sensory subscale improved significantly at T1 (number of words chosen: P = 0.03 and pain rating index: P = 0.03). Impairment level ( P = 0.03) and quality of life (EuroQol P = 0.04, SF-36 physical P = 0.01) were significantly improved at T12. No improvement was found for skin sensitivity and functional limitations. Conclusion. Intravenous magnesium significantly improved pain, impairment and quality of life and was well tolerated. The results of this pilot study are encouraging and suggest that magnesium IV as a treatment in CRPS 1 should be further explored in a large size formal trial design. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|