Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children
| Autor: | Gerolamo Sibilio, Carla Di Carluccio, Eduardo Sanguigno, Procolo Di Bonito, Francesco Saitta, Brunella Capaldo, Carolina Scilla, Nicola Moio, Claudia Forziato, Luigi Cavuto, Maria Rosaria Iardino |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Cardiovascular and Metabolic Risk Homocysteine Adolescent Endocrinology Diabetes and Metabolism Population Disease Overweight White People chemistry.chemical_compound Risk Factors Diabetes mellitus Internal medicine Outpatients Internal Medicine medicine Humans Obesity education Child Triglycerides Original Research Advanced and Specialized Nursing education.field_of_study Cholesterol business.industry Cholesterol HDL medicine.disease Endocrinology chemistry Cardiovascular Diseases Echocardiography Population study Female Hypertrophy Left Ventricular medicine.symptom business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 |
| Popis: | OBJECTIVE To evaluate whether the high triglyceride-to-HDL cholesterol (TG-to-HDL-C) ratio is associated with cardiometabolic risk (CMR) factors and preclinical signs of organ damage in an outpatient population of white children and adolescents. RESEARCH DESIGN AND METHODS The study population included 884 subjects (aged 6–16 years), of whom 206 (23%) were normal weight, 135 (15%) were overweight, and 543 (61%) were obese. Biochemical variables were analyzed in the whole sample, whereas homocysteine and left ventricular (LV) geometry and function were evaluated in 536 and 258 children, respectively. RESULTS The percentage of pubertal children (P < 0.001), as well as measurements of BMI, waist circumference, homeostasis model assessment of insulin resistance, white blood cell count, alanine aminotransferase (ALT), systolic blood pressure (P < 0.0001, for all), creatinine (P < 0.001), and diastolic blood pressure (P < 0.02), increased from the lowest to the highest tertile of the TG-to-HDL-C ratio. Age, sex, homocysteine, and glomerular filtration rate did not change. Moreover, interventricular septum thickness, relative wall thickness, and LV mass index (P = 0.01 to P < 0.0001) increased across tertiles of the TG-to-HDL-C ratio. Children with a TG-to-HDL-C ratio ≥2.0 showed a two- to threefold higher risk of elevated ALT levels and concentric LV hypertrophy than those with a TG-to-HDL-C ratio CONCLUSIONS The high TG-to-HDL-C ratio is associated with several CMR factors and preclinical signs of liver and cardiac abnormalities in the outpatient, white pediatric population. Thus, a TG-to-HDL-C ratio ≥2.0 may be useful in clinical practice to detect children with a worsened CMR profile who need monitoring to prevent cardiovascular disease in adulthood. |
| Databáze: | OpenAIRE |
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