The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products
| Autor: | Antonio Romito, Christophe Huret, Edith Heard, Rafael Galupa, Giulia Furlan, Joke Gerarda van Bemmel, Céline Morey, Claire Rougeulle, Nancy Gutierrez Hernandez |
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| Přispěvatelé: | Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Génétique et Biologie du Développement, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Chaire Epigénétique et mémoire cellulaire, Collège de France (CdF (institution)), Developmental Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
X Chromosome Transcription Genetic [SDV]Life Sciences [q-bio] Biology X-inactivation Cell Line 03 medical and health sciences Mice Transcription (biology) X Chromosome Inactivation Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Molecular Biology Gene X chromosome ComputingMilieux_MISCELLANEOUS Genetics Mammals RNA Cell Biology Long non-coding RNA 030104 developmental biology HEK293 Cells CTCF XIST Female RNA Long Noncoding |
| Zdroj: | Molecular Cell Molecular Cell, Elsevier, 2018, 70 (3), pp.462-472.e8. ⟨10.1016/j.molcel.2018.03.024⟩ Molecular Cell, 70(3), 462-+. Cell Press |
| ISSN: | 1097-2765 |
| Popis: | Summary Accumulation of the Xist long noncoding RNA (lncRNA) on one X chromosome is the trigger for X chromosome inactivation (XCI) in female mammals. Xist expression, which needs to be tightly controlled, involves a cis -acting region, the X-inactivation center ( Xic ), containing many lncRNA genes that evolved concomitantly to Xist from protein-coding ancestors through pseudogeneization and loss of coding potential. Here, we uncover an essential role for the Xic -linked noncoding gene Ftx in the regulation of Xist expression. We show that Ftx is required in cis to promote Xist transcriptional activation and establishment of XCI. Importantly, we demonstrate that this function depends on Ftx transcription and not on the RNA products. Our findings illustrate the multiplicity of layers operating in the establishment of XCI and highlight the diversity in the modus operandi of the noncoding players. |
| Databáze: | OpenAIRE |
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