Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
| Autor: | Akio Kazusaka, Tomoyuki Matsumoto, Nobuo Sasaki, Yoshinori Ikenaka, Mayumi Ishizuka, Shoichi Fujita |
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| Rok vydání: | 2011 |
| Předmět: |
animal structures
Furazolidone medicine.drug_class Health Toxicology and Mutagenesis Cytochrome P450 Pharmacology Reductase NADPH cytochrome P450 reductase medicine Microsomal enzymes Nitrofuran Antibacterial agent chemistry.chemical_classification biology General Medicine Metabolism Chicken Enzyme Liver Biochemistry chemistry biology.protein Agronomy and Crop Science medicine.drug |
| Zdroj: | Pesticide Biochemistry and Physiology. 100:135-139 |
| ISSN: | 0048-3575 |
| DOI: | 10.1016/j.pestbp.2011.02.013 |
| Popis: | The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to identify the enzyme that contributes to FZ metabolism in chickens. Wistar rats and White Leghorn chickens were administered FZ once a day for four consecutive days. FZ metabolism was accelerated by FZ administration in chickens, but not in rats. The elevation of FZ metabolism coincided with the induction of NADPH cytochrome P450 reductase (CPR) activity in chickens, but such induction was not observed in rats. FZ metabolizing activities were inhibited in the presence of a CPR inhibitor (diphenylene iodonium chloride) but not by the addition of archetypal cytochrome P450 inhibitors (CO or n-octylamine). The preset study concluded that FZ accelerated its own metabolism in the chicken by induction of the activity of CPR. |
| Databáze: | OpenAIRE |
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