Inhaled cisplatin deposition and distribution in lymph nodes in stage II lung cancer patients
| Autor: | Wolfgang Hohenforst-Schmidt, Anna Katsavou, Thomas J. Vogl, George Stamatis, Konstantinos Zarogoulidis, Antonis Papaiwannou, Paul Zarogoulidis, Lutz Freitag, George A. Zachariadis, Kaid Darwiche, Leslie Krauss, Haidong Huang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Lung Neoplasms medicine.medical_treatment Medizin Antineoplastic Agents Targeted therapy Internal medicine Administration Inhalation medicine Humans Distribution (pharmacology) Tissue Distribution Lung cancer Lymph node Neoplasm Staging Cisplatin Chemotherapy business.industry General Medicine medicine.disease medicine.anatomical_structure Cancer cell Lymph Nodes Lymph business medicine.drug |
| Zdroj: | Future Oncology. 9:1307-1313 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon.13.111 |
| Popis: | Lung cancer therapies during the last decade have focused on targeting the genome of cancer cells, and novel routes for administering lung cancer therapies have been investigated for decades. Aerosol therapies for several systematic diseases and systemic infections were introduced into the market a decade ago. One of the main issues of aerosol therapies has been the ability to investigate the deposition of a drug compound throughout the systematic circulation and lymph node circulation. Until now, none of the published studies have efficiently shown the deposition of a chemotherapy pharmaceutical within the lymph node tissue. In our current work we present, for the first time, with the novel CytoViva® (AL, USA) technique, the deposition of cisplatin aerosol therapy in surgically resected stage II lymph nodes from lung cancer patients. Finally, we present the distribution of cisplatin in correlation with the cisplatin concentration in different lymph stations and comment on the possible mechanisms of distribution. |
| Databáze: | OpenAIRE |
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