Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance
| Autor: | Marjan Ghorbani, Nima Abdyazdani, Parinaz Nezhad-Mokhtari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Curcumin
Chemical Phenomena Cell Survival Zein Ogg Fibroin Microbial Sensitivity Tests macromolecular substances 02 engineering and technology Galactans complex mixtures Biochemistry Cell Line Mannans Mice 03 medical and health sciences chemistry.chemical_compound Anti-Infective Agents Tissue engineering Structural Biology Plant Gums Animals Thermal stability Molecular Biology 030304 developmental biology 0303 health sciences Guar gum Tissue Scaffolds Chemistry Spectrum Analysis technology industry and agriculture Hydrogels General Medicine computer.file_format Bombyx 021001 nanoscience & nanotechnology Chemical engineering Thermogravimetry Self-healing hydrogels Nanoparticles Fibroins Rheology 0210 nano-technology Wound healing Oxidation-Reduction computer |
| Zdroj: | International Journal of Biological Macromolecules. 167:59-65 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2020.11.103 |
| Popis: | Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application. |
| Databáze: | OpenAIRE |
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