Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)
| Autor: | John Littell, Alexandre Giandoni Wolkoff, Karladine E. Graves, Russell S. Gonnering, Stella Immanuel, John E. McKinnon, Sabine Hazan, Lee D. Merritt, Brian C. Procter, Richard A. Eisner, Robin L. Armstrong, Donald C. Pompan, Martin Scholz, Michael J. A. Robb, Kelly Victory, Vladimir Zelenko, Peter A. McCullough, Salete da Silva Rios, Richard P. Bartlett, Craig M. Wax, Paul E. Alexander, Vicki Wooll, Robert Berkowitz, Charles E. Geyer, Kristin S. Held, George Fareed, Juliana Cepelowicz Rajter, Harvey A. Risch, Molly Rutherford, Richard G. Urso, Roland Derwand, Adam Brufsky, Teryn Clarke, Lionel H. Lee, Chad Prodromos, Ivette Lozano, Ben Marble, Harpal S. Mangat, Thomas J. Borody, Jane M. Orient, Silvia Nunes Szente Fonseca, John Eck, Joseph H. Brewer, Brian M. Tyson, Angelina Farella, Ramin Oskoui, Joseph A. Ladapo, Marilyn M. Singleton, Andrew C. Berry, Alan F. Bain, Cristian Arvinte, Michael M. Jacobs, Kenneth B. V. Gross, Elizabeth Lee Vliet, Jean-Jacques Rajter, James A. Tumlin, Alieta Eck, H. Thomas Hight, C. Venkata S. Ram |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system corticosteroid Tratamento medicine.drug_class media_common.quotation_subject Leprostatic Agents 030204 cardiovascular system & hematology law.invention 03 medical and health sciences Therapeutic approach 0302 clinical medicine Pharmacotherapy Randomized controlled trial law Epidemiology Pandemic Medicine Humans ambulatory treatment Intensive care medicine Pandemics media_common anti-inflammatory Hospitalização business.industry SARS-CoV-2 Anticoagulant anticoagulant sequenced multidrug therapy COVID-19 General Medicine medicine.disease antiplatelet agent antiviral mortality Telemedicine COVID-19 Drug Treatment anti-infective lcsh:RC666-701 Mortalidade Medicamentos Drug Therapy Combination Cardiology and Cardiovascular Medicine business Cytokine storm Covid-19 hospitalization |
| Zdroj: | Reviews in Cardiovascular Medicine, Vol 21, Iss 4, Pp 517-530 (2020) Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| Popis: | The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. |
| Databáze: | OpenAIRE |
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