Secretion of pancreatic digestive enzymes induced in rats by first-time oral exposure to kidney bean E2L2 lectin is mediated only in part by cholecystokinin (CCK)
| Autor: | T. Atkinson, George Grant, S. Murray, E. C. Ewan, J. E. Edwards, D. A. H. Farningham, A. Pusztai |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Trypsinogen Endocrinology Diabetes and Metabolism Chymotrypsinogen digestive system Secretin chemistry.chemical_compound Endocrinology Internal medicine Gastrins Internal Medicine medicine Animals Phytohemagglutinins Pancreas Gastrin Cholecystokinin Hepatology biology digestive oral and skin physiology Trypsin Rats Kinetics medicine.anatomical_structure chemistry Digestive enzyme biology.protein Trypsin Inhibitor Kunitz Soybean alpha-Amylases hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pancreas. 19(4) |
| ISSN: | 0885-3177 |
| Popis: | The acute effects of kidney bean (Phaseolus vulgaris) E2L2 lectins (PHA) given orally to conscious rats or continually infused into the duodenum of anesthetized rats on blood cholecystokinin (CCK), secretin, and gastrin and on secretion of pancreatic digestive enzymes have been evaluated. PHA increased circulating levels of CCK and secretin but did not alter gastrin. In addition, PHA induced dose-dependent secretion of trypsinogen, chymotrypsinogen, and alpha-amylase by the pancreas in vivo. This pancreas output appeared to be modulated only in part through CCK. Thus pretreatment of rats with a CCK-A receptor antagonist (L-364718) attenuated the immediate (or = 90 min) pancreas secretory response to PHA but could not prevent a PHA-associated increase in digestive enzyme output in the longer term (after 90 min). In contrast, treatment of rats with L-364718 abolished the stimulatory effects of soyabean trypsin inhibitors on digestive enzyme secretion in both the short and long term. Additional mechanisms or hormones, such as secretin, may play a role in modulating later exocrine pancreas responses to PHA. |
| Databáze: | OpenAIRE |
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