Identification of Three Highly Attenuated Salmonella typhimurium Mutants That Are More Immunogenic and Protective in Mice than a Prototypical aroA Mutant
| Autor: | Fred Heffron, Brian P. Devore, Peter J. Valentine |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Salmonella typhimurium
Salmonella Immunology Mutant medicine.disease_cause Vaccines Attenuated Microbiology complex mixtures Immunoglobulin G Mice medicine Animals Hypersensitivity Delayed Mice Inbred BALB C Alkyl and Aryl Transferases biology Aroa Immunogenicity Antibody titer biology.organism_classification Enterobacteriaceae Antibodies Bacterial Bacterial vaccine Infectious Diseases Microbial Immunity and Vaccines Bacterial Vaccines Immunoglobulin A Secretory Mutation biology.protein Parasitology Female 3-Phosphoshikimate 1-Carboxyvinyltransferase |
| Popis: | A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of mutants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher Salmonella -specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than the aroA control strain, after a single oral dose of 1 × 10 9 to 2 × 10 9 bacteria. |
| Databáze: | OpenAIRE |
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