Prevalence of and risk factors for vitamin B12 deficiency in patients with Crohnʼs disease
| Autor: | Stephen J. Rulyak, Peggy D. Headstrom, Scott D. Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Washington medicine.medical_specialty medicine.medical_treatment Population Gastroenterology Postoperative Complications Crohn Disease Ileum Risk Factors Internal medicine Prevalence Humans Immunology and Allergy Medicine Vitamin B12 education Colectomy Retrospective Studies education.field_of_study Crohn's disease business.industry Case-control study Vitamin B 12 Deficiency Retrospective cohort study Odds ratio Middle Aged medicine.disease Ulcerative colitis Surgery Logistic Models Case-Control Studies Multivariate Analysis Female business |
| Zdroj: | Inflammatory Bowel Diseases. 14:217-223 |
| ISSN: | 1078-0998 |
| Popis: | Background: Crohn's disease (CD) can commonly involve the terminal ileum, which is the site of B12 absorption. The aim of this study was to define the prevalence of vitamin B12 abnormalities in a population with CD and to identify risk factors associated with B12 abnormalities in CD. Methods: The medical records of 201 patients with CD evaluated at a tertiary care center were retrospectively reviewed to determine the prevalence of B12 deficiency and to evaluate factors associated with B12 deficiency. The prevalence of B12 deficiency in a control population of 40 patients with ulcerative colitis was also assessed. Results: The prevalence of an abnormal serum B12 concentration in patients with CD was 18.4% (95% confidence interval [CI] 13.1–23.8%) compared with 5% (95% CI, 0–11.8%) (P = 0.035) in ulcerative colitis controls. Risk factors for B12 deficiency in patients with CD included prior ileal (odds ratio [OR], 7.22; 95% CI, 1.97–26.51) or ileocolonic (OR, 5.81; 95% CI, 2.09–16.12) resection and the need for ongoing medical therapy (OR, 2.59; 95% CI, 1.03–6.47). Neither disease location nor duration was independently associated with the risk of B12 deficiency. Conclusions: Vitamin B12 abnormalities are common in patients with CD and patients with a prior ileal or ileocolonic resection are at particular risk. Routine screening for B12 deficiency in patients with CD is warranted. (Inflamm Bowel Dis 2007) |
| Databáze: | OpenAIRE |
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