Galectin-9: From cell biology to complex disease dynamics
| Autor: | Rashmi Mishra, Sebastian John |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gene isoform Linker peptide medicine.medical_treatment Galectins Neoplastic transformations Complex disease General Medicine Disease Immunotherapy Biology General Biochemistry Genetics and Molecular Biology Cell biology 03 medical and health sciences 030104 developmental biology Neoplasms medicine Cell Adhesion Humans General Agricultural and Biological Sciences Receptor Galectin Signal Transduction |
| Zdroj: | Journal of biosciences. 41(3) |
| ISSN: | 0973-7138 |
| Popis: | Galectins is a family of non-classically secreted, beta-galactoside-binding proteins that has recently received considerable attention in the spatio-temporal regulation of surface 'signal lattice' organization, membrane dynamics, cell-adhesion and disease therapeutics. Galectin-9 is a unique member of this family, with two non-homologous carbohydrate recognition domains joined by a linker peptide sequence of variable lengths, generating isoforms with distinct properties and functions in both physiological and pathological settings, such as during development, immune reaction, neoplastic transformations and metastasis. In this review, we summarize the latest knowledge on the structure, receptors, cellular targets, trafficking pathways and functional properties of galectin-9 and discuss how galectin-9-mediated signalling cascades can be exploited in cancers and immunotherapies. |
| Databáze: | OpenAIRE |
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