A Possible Reduction in the Renal Clearance of Ciprofloxacin by Fenbufen in Rats
| Autor: | Kohji Naora, Masakazu Hayashibara, Nobuhiro Ichikawa, Yoshihiro Katagiri, Kikuo Iwamoto |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Urinary system Pharmaceutical Science Pharmacology Pharmacokinetics Ciprofloxacin medicine Animals Bile Chromatography High Pressure Liquid Antibacterial agent Kidney Fenbufen Chemistry Anti-Inflammatory Agents Non-Steroidal Rats Inbred Strains Blood Proteins Drug interaction Phenylbutyrates Rats medicine.anatomical_structure Depression Chemical Renal physiology Injections Intravenous Half-Life Protein Binding medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 42:704-707 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1990.tb06563.x |
| Popis: | The change in plasma concentration-time profile, serum protein binding and renal and biliary clearances of ciprofloxacin caused by coadministration of fenbufen has been studied in rats administered an intravenous dose of ciprofloxacin (5 mg kg−1) alone or with fenbufen (10 mg kg−1). Coadministered fenbufen significantly prolonged the plasma elimination half-life of ciprofloxacin from 40.5 to 57.6 min and tended to reduce the total body clearance of this quinolone by about 20%. The extent of ciprofloxacin binding to rat serum protein was not affected by fenbufen, nor did it affect the biliary clearance of the quinolone. However, fenbufen tended to reduce renal clearance and significantly decreased the cumulative renal excretion of the quinolone during at least the first 3 h after drug administration. These results suggest a possible reduction of ciprofloxacin clearance owing to inhibition of renal excretion by fenbufen. |
| Databáze: | OpenAIRE |
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