Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations
| Autor: | Matthieu Haudiquet, Jorge Moura de Sousa, Marie Touchon, Eduardo P. C. Rocha |
|---|---|
| Přispěvatelé: | Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), We acknowledge the financial support of Equipe FRM (EQU201903007835), Laboratoire d’Excellence IBEID (ANR-10-LABX-62-IBEID), the INCEPTION program (PIA/ANR-16-CONV-0005), the ANR (SALMOPROPHAGE ANR-16-CE16-0029, ENCAPSULATION ANR-18-CE12-0001-01)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), ANR-16-CE12-0029,Salmo_prophages,Co-évolution des génomes bactériens et de leurs prophages: cooptation des prophages et conversion lysogenique chez Salmonella(2016), ANR-18-CE12-0001,ENCAPSULATION,Le rôle évolutif des capsules dans l'adaptation bactérienne(2018), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) |
| Rok vydání: | 2022 |
| Předmět: |
bepress|Life Sciences|Genetics and Genomics|Genomics
plasmids Genetic conflicts bacteriophages Gene Transfer Horizontal bepress|Life Sciences|Genetics and Genomics [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] bepress|Life Sciences|Microbiology|Other Microbiology defencesystems bepress|Life Sciences|Ecology and Evolutionary Biology Biological Evolution General Biochemistry Genetics and Molecular Biology Bacterial evolution Interspersed Repetitive Sequences bepress|Life Sciences satellites [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology bepress|Life Sciences|Microbiology Mobile genetic elements evolution horizontal gene transfer General Agricultural and Biological Sciences bepress|Life Sciences|Ecology and Evolutionary Biology|Evolution |
| Zdroj: | Philosophical Transactions of the Royal Society of London. B (1887–1895) Philosophical Transactions of the Royal Society of London. B (1887–1895), 2022, 377 (1861), pp.20210234. ⟨10.1098/rstb.2021.0234⟩ |
| ISSN: | 1471-2970 0264-3839 |
| DOI: | 10.1098/rstb.2021.0234⟩ |
| Popis: | Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of their hosts. In general, transfer is costly to the donor cell while potentially beneficial to the recipients. The diversity and plasticity of cell–MGEs interactions, and those among MGEs, result in complex evolutionary processes where the source, or even the existence of selection for maintaining a function in the genome, is often unclear. For example, MGE-driven HGT depends on cell envelope structures and defense systems, but many of these are transferred by MGEs themselves. MGEs can spur periods of intense gene transfer by increasing their own rates of horizontal transmission upon communicating, eavesdropping, or sensing the environment and the host physiology. This may result in high-frequency transfer of host genes unrelated to the MGE. Here, we review how MGEs drive HGT and how their transfer mechanisms, selective pressures and genomic traits affect gene flow, and therefore adaptation, in microbial populations. The encoding of many adaptive niche-defining microbial traits in MGEs means that intragenomic conflicts and alliances between cells and their MGEs are key to microbial functional diversification. This article is part of a discussion meeting issue ‘Genomic population structures of microbial pathogens’. |
| Databáze: | OpenAIRE |
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