The effects of resveratrol on chronic constriction injury of sciatic nerve in rats
| Autor: | T. Ozcana, L.G. Kamanga, Nevin Ersoy, Caner Çetinkaya, Husnu Alper Bagriyanik, D. Kutri, Muge Kiray, E. Ikizoglu |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty animal structures medicine.medical_treatment Constriction Pathologic Resveratrol Motor Activity Open field Antioxidants chemistry.chemical_compound Peripheral Nerve Injuries Stilbenes Medicine Animals Insulin-Like Growth Factor I Rats Wistar Saline Treated group business.industry General Neuroscience Motor impairment Immunohistochemistry Sciatic Nerve nervous system diseases Neuroprotective Agents chemistry Anesthesia Constriction injury Chronic Disease Sciatic nerve business psychological phenomena and processes |
| Popis: | The aim of this study was to investigate the effects of resveratrol (RVT) in chronic constriction injury (CCI) of sciatic nerve by behavioral, histomorphological and immunohistochemical evaluations in rats. In this study, male Wistar rats were divided into three groups: sham (n = 7), CCI+saline (n = 7) and CCI+RVT (n = 7). After inducing CCI, treatment with 10 mg/kg/day of RVT or saline for 14 days was given. Locomotor function was assessed with rota-rod and open field tests. Morphologic alterations of sciatic nerve were assessed histologically by light and electron microscopy. Immunohistochemistry for insulin-like growth factor-1 (IGF-1) were performed. RVT treatment prevented motor impairment and histomorphological alterations caused by chronic constriction injury of sciatic nerve. IGF-1 immunoreactivity was significantly higher in RVT treated group then CCI induced group and positive correlated with morphometric parameters. These results indicate that RVT may reduce CCI induced damage and this effect may be mediated through the restoration of IGF-1 immunoreactivity. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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