The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China
| Autor: | Jing Li, Dong Hu, Ligong Fu, Dawei He, Deng Jiuzheng, Kai Xu, Jianjin Zhu, Wen-Hao Hu, Song-Hua Xiao, Yan Wang, Dai-Xu Wei, Hua-Wei Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China medicine.medical_specialty Single-nucleotide polymorphism Receptors Fc Polymorphism Single Nucleotide Gastroenterology Asian People Risk Factors Polymorphism (computer science) Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Spondylitis Ankylosing Genotyping Genetic association Ankylosing spondylitis business.industry General Medicine medicine.disease Case-Control Studies Female Gene polymorphism Restriction fragment length polymorphism business |
| Zdroj: | Medical Science Monitor. 26 |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.920956 |
| Popis: | BACKGROUND The study aimed to explore the genetic association of Fc receptor-like 5 (FCRL5) gene variants (rs6427384 and rs6692977) with ankylosing spondylitis risk in Chinese Han population. MATERIAL AND METHODS Genotyping for FCRL5 gene variations rs6427384 and rs6692977 was implemented among 130 ankylosing spondylitis cases and 135 healthy persons, through polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Frequency dissimilarity for 2 polymorphisms was compared between 2 groups using chi-square test. The association strength of FCRL5 gene polymorphism with ankylosing spondylitis risk was estimated by odds ratios with 95% confidence intervals. RESULTS The frequencies of rs6427384 CC genotype and C allele were significantly lower in the case group than that in the control group (P |
| Databáze: | OpenAIRE |
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