Recurrent disseminated intravascular coagulation and fulminant intra hepatic thrombosis in a patient with the anti-phospholipid syndrome
| Autor: | A. Murray, J. Jackson, Michael R. Harrison, C. Feighery, F. Jackson, G. McDonald, G. Tomkin, J. Stinson |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Fulminant Budd-Chiari Syndrome Gastroenterology Antibodies Autoimmune Diseases Liver disease Internal medicine Consumptive Coagulopathy medicine Coagulopathy Humans Phospholipids Disseminated intravascular coagulation Systemic lupus erythematosus business.industry Syndrome Hematology Disseminated Intravascular Coagulation medicine.disease Thrombosis Surgery Female business Hepatic Thrombosis |
| Zdroj: | American Journal of Hematology. 35:281-282 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.2830350413 |
| Popis: | We describe a patient with the lupus anti-coagulant who had recurrent episodes, over a 2 year period, of a severe and disseminated intravascular coagulopathy. This patient also had positive serological assays for syphilis and anti-cardiolipin antibodies. Associated with the coagulopathy were co-expressed episodes of liver disease, ultimately terminating in fulminant liver failure. At autopsy the features were characteristic of the Budd-Chiari syndrome. This is the first report to document how consumptive coagulopathy may present as a dominant feature of the anti-phospholipid syndrome. It also clearly describes an immune mediated thrombotic mechanism as a cause of hepatic veno-occlusive disorders. Furthermore, this case highlights the varied clinical spectrum of the anti-phospholipid syndrome and suggests that a high index of suspicion is required to ensure its diagnosis. |
| Databáze: | OpenAIRE |
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