Functional impairment in Posttraumatic Stress Disorder: A systematic review and meta-analysis
| Autor: | Lena Jellestad, Jan Taeymans, Jolanda Malamud, Christoph Mueller-Pfeiffer, Nicolà A. Vital |
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| Přispěvatelé: | University of Zurich, Jellestad, Lena |
| Rok vydání: | 2021 |
| Předmět: |
Functional impairment
business.industry Early detection 610 Medicine & health 030227 psychiatry Stress Disorders Post-Traumatic 2738 Psychiatry and Mental Health 03 medical and health sciences Psychiatry and Mental health Posttraumatic stress 10057 Klinik für Konsiliarpsychiatrie und Psychosomatik 0302 clinical medicine Systematic review International Classification of Functioning Disability and Health Meta-analysis Self care Humans Medicine Observational study business 2803 Biological Psychiatry 030217 neurology & neurosurgery Biological Psychiatry Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 136:14-22 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2021.01.039 |
| Popis: | Posttraumatic Stress Disorder (PTSD) is a serious and debilitating condition often associated with significant impairments in daily functioning. To date, research on the complexity of functional impairment in individuals with PTSD is scarce and only limited. Yet, a quantitative synthesis and comprehensive review of existing evidence is needed to better characterize the magnitude of functional impairment in PTSD in distinct domains. We conducted a systematic literature search including observational studies comparing functioning of individuals with and without PTSD. Random effects meta-analyses were performed for the different functional domains according to the WHO International Classification of Functioning, Disability and Health (ICF). The protocol followed the MOOSE guidelines for systematic reviews. A total of thirty-four studies comprising 14 206 participants were included in the study. Compared to healthy individuals, subjects with PTSD showed significant (ps 0.001) impairments with large to very large effect sizes (ds 1) in all domains. Subjects with, compared to without, PTSD showed significant (ps 0.001) impairments with medium to large effect sizes (ds 0.5) in the domains General Tasks and Demands, Mobility, Self Care, Domestic Life, Interpersonal Interactions and Relationships, Major Life Areas and Community, Social and Civic Life. Significant impairments with small to medium effect sizes in the same domains were observed comparing PTSD to other mental disorders. In conclusion, PTSD has a significant impact on most areas of daily functioning as conceptualized in the International Classification of Functioning, Disability and Health (ICF) of the WHO. Early detection and targeted treatment of functional deficits is warranted in this patient population. |
| Databáze: | OpenAIRE |
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