Cytokines and chemokines involved in osteoarthritis pathogenesis

Autor: Dragan Primorac, Uršula Prosenc Zmrzljak, Ivan Kodvanj, Vilim Molnar, Igor Borić, Mario Starešinić, Borut Dobričić, Srećko Sabalić, Eduard Rod, Damir Hudetz, Roko Bjelica, Vid Matišić, Željko Jeleč, Dinko Vidović, Rok Košir, Trpimir Vrdoljak, Fabijan Čukelj, Darko Antičević, Tadija Petrović
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Chemokine
Osteoarthritis / pathology
chemokines
Review
Osteoarthritis
Disease
Pathogenesis
biomarker
cytokines
inflammation
osteoarthritis
pathogenesis
Chemokines / metabolism
Osteoarthritis / etiology
Medicine
Biology (General)
Spectroscopy
biology
General Medicine
Computer Science Applications
Chemistry
Disease Susceptibility
Inflammation Mediators
medicine.symptom
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
QH301-705.5
Inflammation
Catalysis
Proinflammatory cytokine
Inorganic Chemistry
Immune system
Inflammation Mediators / metabolism
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
business.industry
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences
Organic Chemistry
Osteoarthritis / metabolism
medicine.disease
Biomarker (cell)
Cytokines / metabolism
Immunology
biology.protein
business
Biomarkers
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 9208, p 9208 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17
ISSN: 1422-0067
Popis: Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The pathogenesis of this degenerative process is not completely understood; however, a low-grade inflammation leading to an imbalance between anabolic and katabolic processes is a well-established factor. The complex network of cytokines regulating these processes and cell communication has a central role in the development and progression of osteoarthritis. Concentrations of both proinflammatory and anti-inflammatory cytokines were found to be altered depending on the osteoarthritis stage and activity. In this review, we analyzed individual cytokines involved in the immune processes with an emphasis on their function in osteoarthritis.
Databáze: OpenAIRE
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