Pregnancy-Induced Hypertension is Accompanied by Decreased Number of Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells
| Autor: | Agata Ledwozyw, Danuta Dus, Andrzej Czekański, Aneta Kantor, Jerzy Heimrath, Maria Paprocka |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
CD31 medicine.medical_specialty Endothelium Circulating endothelial cell Short Communication Immunology CD34 Cell Count Cell Separation CECs Endothelial progenitor cell Preeclampsia Young Adult chemistry.chemical_compound Antigens CD Pregnancy Internal medicine medicine Humans Immunology and Allergy Endothelial dysfunction Endothelial Progenitor Cells Wound Healing business.industry Endothelial Cells Hypertension Pregnancy-Induced General Medicine Flow Cytometry medicine.disease Vascular Endothelial Growth Factor Receptor-2 Vascular endothelial growth factor Endocrinology medicine.anatomical_structure chemistry Blood Circulation EPCs cardiovascular system Female business circulatory and respiratory physiology |
| Zdroj: | Archivum Immunologiae et Therapiae Experimentalis |
| ISSN: | 1661-4917 0004-069X |
| DOI: | 10.1007/s00005-014-0278-x |
| Popis: | Maternal endothelial dysfunction is one of the main features of pregnancy-induced hypertension (PIH). It is generally accepted that circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) reflect the state of the endothelium, its injury and/or repair possibilities. The objective of this study was to determine whether the CECs and EPCs numbers in the circulation of women with PIH reflect the presence of this pathology. Peripheral blood cells of PIH and normotensive pregnant women were labeled with specific monoclonal antibodies. For CECs evaluation, samples were labeled with anti-CD31 and anti-CD45 antibodies; for EPCs with anti-VEGFR2/KDR and anti-CD34 antibodies. Cells were quantified by flow cytometry. The levels of both CECs (CD31(+), CD45(-)) and EPCs (CD34(+), VEGFR2/KDR(+)) in the peripheral blood of women with PIH were significantly lower compared with those of control pregnant women with normal blood pressure level. Lowered accessibility of maternal CECs and EPCs may diminish general regenerative potential of the patient endothelia, contributing to PIH symptoms and to the risk of subsequent coronary and arterial disease. |
| Databáze: | OpenAIRE |
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