Quantitative trait loci that modify the sootiness of yellow pigmentation in KK-A(y)/a mice
| Autor: | Harumichi Yamanaka, Kazumasa Wakamatsu, Jun-ichi Suto, Kenji Sekikawa, Shosuke Ito |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Genotype Genetic Linkage Congenic Locus (genetics) Mice Inbred Strains Biology Quantitative trait locus Mice Quantitative Trait Heritable Gene mapping Inbred strain Genetic linkage Genetics Animals Allele Hair Color Alleles Chromatography High Pressure Liquid Crosses Genetic Melanins Monophenol Monooxygenase Chromosome Mapping Mice Inbred C57BL Phenotype Female Lod Score Microsatellite Repeats |
| Zdroj: | Mammalian genome : official journal of the International Mammalian Genome Society. 11(8) |
| ISSN: | 0938-8990 |
| Popis: | Compared with C57BL/6J-A(y)/a, KK-A(y)/a mice have yellow fur that is markedly darker. Furthermore, there is a considerable variation in the tone of color with a continuous range in F(2) progeny produced from C57BL/6J females and KK-A(y)/a males. The aims of this study are to reveal the phenotypic differences between the two A(y) congenic strains and to elucidate the genetic factors responsible for the sooty yellow pigmentation in the KK background. On the basis of a chemical analysis, the sootiness in KK-A(y)/a was the result of increased eumelanin (PTCA) and decreased pheomelanin (AHP). A statistically significant QTL was identified on Chromosome (Chr) 15, responsible for the AHP content. No significant loci responsible for PTCA were identified. On the other hand, on the basis of an optical analysis for color difference and overall sootiness, significant evidence of linkage was identified on the proximal part of Chr 15, in the region similar to AHP QTL. The overall sootiness is thus controlled solely by the locus on Chr 15 in F(2) progeny; however, the KK allele at this locus significantly increased the AHP content. |
| Databáze: | OpenAIRE |
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