Macrophages in bacterial lung diseases: phenotype and functions (review)
| Autor: | E. G. Churina, A. V. Sitnikova, O. I. Urazova, S. P. Chumakova, M. V. Vins, A. E. Beresneva, V. V. Novitskii |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Inflammation Disease Biology immune response 03 medical and health sciences 0302 clinical medicine Immune system medicine Macrophage innate immunity lung diseases Innate immune system alveolar macrophages Phenotype macrophages 030104 developmental biology Bacterial etiology 030220 oncology & carcinogenesis Immunology Medicine Molecular Medicine medicine.symptom monocytes Function (biology) |
| Zdroj: | Bûlleten' Sibirskoj Mediciny, Vol 18, Iss 1, Pp 142-154 (2019) |
| ISSN: | 1819-3684 1682-0363 |
| DOI: | 10.20538/1682-0363-2019-1-142-154 |
| Popis: | This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from pro-inflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy. |
| Databáze: | OpenAIRE |
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