LPIN1 is a new target gene for essential hypertension
| Autor: | Keisuke Yatsu, Koichiro Sumida, Tatsuya Haze, Moe Ozawa, Yusuke Kobayashi, Kouichi Tamura, Nobuhito Hirawa, Yuki Ohki, Akira Fujiwara, Nao Ichihara, Shiro Komiya, Hiromichi Wakui |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Phosphatidate Phosphatase Adipose tissue Essential hypertension Mice Insulin resistance Internal medicine Renin–angiotensin system Internal Medicine medicine Glucose homeostasis Animals business.industry fungi Hypertriglyceridemia Fatty liver medicine.disease Fatty Liver Endocrinology Blood pressure Adipose Tissue Essential Hypertension Cardiology and Cardiovascular Medicine business Genome-Wide Association Study |
| Zdroj: | Journal of hypertension. 40(3) |
| ISSN: | 1473-5598 |
| Popis: | Background We previously showed Lipin1 (LPIN1) to be a candidate gene for essential hypertension by genome-wide association studies. LPIN1 encodes the Lipin 1 protein, which contributes to the maintenance of lipid metabolism and glucose homeostasis. However, little is known about the association between LPIN1 and blood pressure (BP). Methods We evaluated the BP of LPIN1-deficient [fatty liver dystrophy (fld)] mice and explored related mechanisms. Results Fld mice have very low expression of LPIN1 and exhibit fatty liver, hypertriglyceridemia, insulin resistance and peripheral neuropathy. Fld mice had significantly elevated SBP and heart rate (HR) throughout the day as measured by a radiotelemetric method. Diurnal variation of SBP and HR was also absent in fld mice. Furthermore, urinary excretion of adrenaline and noradrenaline by fld mice was significantly higher compared with that of control mice. The BP response of fld mice to clonidine (a centrally acting α2-adrenergic receptor agonist) was greater than that of control mice. However, levels of Angiotensinogen and Renin 1 mRNA and urinary nitric oxide excretion were comparable between the two groups. The decrease in SBP at 8 weeks after fat grafting surgery was significantly greater in the transplant group compared with the sham operated group. Conclusion The elevated BP in fld mice may result from activation of the sympathetic nervous system through decreased levels of adipose cytokines. These results indicate that LPIN1 plays a crucial role in blood pressure regulation and that LPIN1 is a new target gene for essential hypertension. |
| Databáze: | OpenAIRE |
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