The Effect of Levamisole on Peripheral T-Lymphocytes of Patients with Malignant Lymphomas
| Autor: | U. Butturini, G. Tridente, P. Sansoni, A. Rossetti |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Rosette Formation Lymphoma T-Lymphocytes Lymphocyte Immunology Lymphocyte Activation Toxicology Internal medicine medicine Humans Inverse correlation Pharmacology DNA synthesis business.industry Levamisole medicine.disease Hodgkin Disease In vitro Peripheral medicine.anatomical_structure Endocrinology Regression Analysis Mitogens business Statistical correlation medicine.drug |
| Zdroj: | Journal of Immunopharmacology. 4:223-232 |
| ISSN: | 0163-0571 |
| DOI: | 10.3109/08923978209026436 |
| Popis: | The effect of various concentrations (0.015 - 10 micrograms/ml) of Levamisole (LMS) on the peripheral lymphocytes of patients with malignant lymphomas (ML) and normal donors was investigated in vitro. The parameters studied include: E rosettes forming cells (total T lymphocytes), active E rosettes (early T lymphocytes) and DNA synthesis induced by pitogens PHA and Con A. LMS improved significantly lymphocyte response both in patients with ML and normal donors when the cells were stimulated by Con A. In both groups no significant effect was observed on the response to PHA nor on the percentage of E-rosettes, whereas the mean number of active E rosettes was significantly increased on all concentrations of the drug. While in the normal subjects a positive statistical correlation between active E-rosettes and Con A response was observed, in patients with ML an inverse correlation was found. This latter correlation was partially reversed by LMS. These results indicate that LMS, both in normals and in patients with ML, interacts with a specific cell subset (early rosetting lymphocytes), with different functions in normal and pathological situations. The drug shows an effect on the immunological handicap of lymphocytes of patients with ML. |
| Databáze: | OpenAIRE |
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