FEATURES OF KIDNEY DAMAGE IN HIV-INFECTED
| Autor: | M.O. Sokolenko, M.O. Andrushchak, V.D. Moskalyuk, I.V. Balanyuk, Y.I. Boyko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
hiv infection chronic kidney disease tubulointerstitial lesions glomerular kidney lesions medicine.medical_treatment 030232 urology & nephrology Urology Renal function Urine 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine medicine Renal replacement therapy Kidney transplantation Kidney Proteinuria business.industry urogenital system medicine.disease medicine.anatomical_structure Albuminuria Medicine medicine.symptom business Kidney disease |
| Zdroj: | Медична наука України, Vol 17, Iss 1, Pp 29-34 (2021) |
| ISSN: | 2664-4738 |
| Popis: | Relevance. In HIV-infected patients, renal disease, which is characterized by severe clinical manifestations, can significantly affect the prognosis of life. Given the growing number of HIV-infected people in the world and the increase in the life expectancy of such patients, an increase in the number of HIV-infected people in need of expensive renal replacement therapy, as well as kidney transplantation, should be expected. But the question of the nature of kidney damage in HIV infection in Ukraine is still insufficiently covered. The objective of the work is to establish the clinical and laboratory features of kidney damage in HIV infection. Materials and methods. 292 patients with HIV were examined. Screening for markers of kidney damage (albuminuria/proteinuria) was performed by test systems (using urine strips). The results obtained with the help of test strips were considered as indicative. In the presence of ≥1+ proteinuria in the screening test, which corresponded to a gradation of 30 mg/l, repeated urine analyzes were performed with quantitative determination of protein on a spectrophotometer, separated in time from 3 days to one week. The functional state of the kidneys was assessed by an integrated indicator that characterizes the degree of preservation/loss of mass of active nephrons. The criterion for renal impairment was a decrease in glomerular filtration rate (GFR) |
| Databáze: | OpenAIRE |
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