Effect of maternal progesterone exposure on fetal testosterone in mice
| Autor: | G. Pointis, M.O. Richard, M.-T. Latreille, P.D. D'Athis, Lise Cedard |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Sex Differentiation Ratón Gestational Age Biology Testicle Subcutaneous injection Mice Fetal mouse Pregnancy Internal medicine medicine Animals Testosterone Progesterone Fetus Dose-Response Relationship Drug medicine.disease Fetal Blood Endocrinology medicine.anatomical_structure Pediatrics Perinatology and Child Health Gestation Female Developmental Biology |
| Zdroj: | Biology of the neonate. 45(4) |
| ISSN: | 0006-3126 |
| Popis: | The effect of maternal exposure to progesterone on plasma testosterone levels was studied in fetal mice. A daily subcutaneous injection of 2 mg progesterone to mice from day 14 to 17 of pregnancy resulted in a significant decline of circulating testosterone levels in male fetuses (p < 0.05). A single injection of progesterone to mothers on day 18 of pregnancy leads to the same effect in male fetuses but increased significantly plasma testosterone levels in female ones (p < 0.01). The testes of fetuses from progesterone-exposed mothers produced in vitro less testosterone than those of controls (p < 0.01). These results show that both long- and short-term maternal exposure to pharmacological concentrations of progesterone reduce testosterone production in the male fetus. The nature of this mechanism is yet unknown, but it is suggested that the change of plasma testosterone levels may result from a local inhibition of the fetal testicular function. |
| Databáze: | OpenAIRE |
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