A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy
| Autor: | Adileh Ayati, Maliheh Safavi, Setareh Moghimi, Somayeh Salarinejad, Alireza Foroumadi, Behjat Pouramiri |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Cancer therapy Antineoplastic Agents 01 natural sciences Biochemistry Targeted therapy Drug Discovery medicine Humans Clinical efficacy Epidermal growth factor receptor Epigenetics Molecular Biology Protein Kinase Inhibitors EGFR inhibitors Cell Proliferation biology Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Cancer medicine.disease 0104 chemical sciences ErbB Receptors 010404 medicinal & biomolecular chemistry Cancer cell Cancer research biology.protein Drug Screening Assays Antitumor |
| Zdroj: | Bioorganic chemistry. 99 |
| ISSN: | 1090-2120 |
| Popis: | The identification of molecular agents inhibiting specific functions in cancer cells progression is considered as one of the most successful plans in cancer treatment. The epidermal growth factor receptor (EGFR) over-activation is observed in a vast number of cancers, so, targeting EGFR and its downstream signaling cascades are regarded as a rational and valuable approach in cancer therapy. Several synthetic EGFR tyrosine kinase inhibitors (TKIs) have been evaluated in recent years, mostly exhibited clinical efficacy in relevant models and categorized into first, second, third and fourth-generation. However, studies are still ongoing to find more efficient EGFR inhibitors in light of the resistance to the current inhibitors. In this review, the importance of targeting EGFR signaling pathway in cancer therapy and related epigenetic mutations are highlighted. The recent advances on the discovery and development of different EGFR inhibitors and the use of various therapeutic strategies such as multi-targeting agents and combination therapies have also been reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect