Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel

Autor: Kok-Gan Chan, Jonathan V. Sweedler, Kar-Wai Hong, Ahmad Yamin Abdul Rahman, Colin Campbell, André S. Mecawi, Mark F. Rogers, Yea Ling Tay, Fatma Zohra Djazouli Alim, Mohammad Rais Mustafa, José Antunes-Rodrigues, Nicole Mahy, Elena V. Romanova, Bruce R. Southey, David Murphy, Michael P Greenwood, Charles C.T. Hindmarch
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Pituitary gland
Vasopressin
Arginine
Pathology and Laboratory Medicine
Nervous System
Biochemistry
CAMELOS
0302 clinical medicine
Camels
Animal Cells
Medicine and Health Sciences
Post-Translational Modification
Dehydration (Medicine)
Mammals
Neurons
Multidisciplinary
Eukaryota
Adaptation
Physiological
medicine.anatomical_structure
Pituitary Gland
Vertebrates
Medicine
Seasons
Cellular Types
Anatomy
Signal Peptides
Research Article
Hypothalamo-Hypophyseal System
medicine.medical_specialty
endocrine system
Camelus
Summer
Science
Neuropeptide
Endocrine System
Biology
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Animals
Gene Expression Profiling
Winter
Organisms
Biology and Life Sciences
Proteins
Cell Biology
Neuronal Dendrites
Fold change
Neuroanatomy
030104 developmental biology
Endocrinology
Cellular Neuroscience
Amniotes
Earth Sciences
Ultrastructure
030217 neurology & neurosurgery
Neuroscience
Antidiuretic
Hormone
Zdroj: Alim, F Z D, Romanova, E V, Tay, Y L, Rahman, A Y B A, Chan, K G, Hong, K W, Rogers, M, Southey, B R, Greenwood, M P, Mecawi, A S, Mustafa, M R, Mahy, N, Campbell, C, Antunes-Rodrigues, J, Sweedler, J V, Murphy, D & Hindmarch, C C T 2019, ' Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel ', PLoS ONE, vol. 14, no. 6, e0216679 . https://doi.org/10.1371/journal.pone.0216679
PLoS ONE, Vol 14, Iss 6, p e0216679 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
DOI: 10.1371/journal.pone.0216679
Popis: The “ship” of the Arabian and North African deserts, the one-humped dromedary camel (Camelus dromedarius) has a remarkable capacity to survive in conditions of extreme heat without needing to drink water. One of the ways that this is achieved is through the actions of the antidiuretic hormone arginine vasopressin (AVP), which is made in a specialised part of the brain called the hypothalamo-neurohypophyseal system (HNS), but exerts its effects at the level of the kidney to provoke water conservation. Interestingly, our electron microscopy studies have shown that the ultrastructure of the dromedary HNS changes according to season, suggesting that in the arid conditions of summer the HNS is in an activated state, in preparation for the likely prospect of water deprivation. Based on our dromedary genome sequence, we have carried out an RNAseq analysis of the dromedary HNS in summer and winter. Amongst the 171 transcripts found to be significantly differentially regulated (>2 fold change, p value
Databáze: OpenAIRE
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